Male Contraceptive Pill Proves Successful In Human Trial

The promise of a reliable and safe male oral contraceptive pill just got a lot closer. Reporting in the Journal of Clinical Endocrinology and Metabolism, scientists have declared the success of a phase 1 study looking at the safety and tolerability of a brand-new family planning pill for men.

After taking the pill for a month, the three men suffered a change in hormones that would cause a drop in sperm yield. Crucially, they reported relatively few side-effects- even most of the men’s libidos remained unchanged- and the contraceptive effects were reversible after stopping treatment.

The researchers still need to carry out greater and longer studies, as well as tests on sexually active pairs, but they hope their work could lead to a brand-new male contraceptive alternative in a decade.

“Our ensues suggest that this capsule, which combines two hormonal activities in one, will be increased sperm yield while preserving libido, ” Christina Wang, Los Angeles Biomedical Research Institute and Harbor UCLA Medical Center, said in a statement.

“Safe, reversible hormonal male contraception should be available in about 10 times, ” Wang predicted.

The pill, known as 11-beta-MNTDC, contains a modified sort of testosterone that has the blended actions of the androgen and progesterone. Progesterone works to block the production of hormones called LH and FSH that are needed for the testes to make testosterone and sperm, while androgen- a male hormone- helps to counteract the declines in testosterone. The squad describes 11 -beta-MNTDC as a “sister compound” to another experimental male oral contraceptive pill, DMAU, which the same team published develops about last year.

For 28 periods, 30 healthy humen took the pill in one of two doses of 11-beta-MNTDC; 14 people received 200 milligrams and 16 took the 400 -milligram dose. Meanwhile, a further 10 healthy humankinds took a placebo capsule for the same time.

The researchers did not actually go looking for changes in seman make, as the drug would take months to have this impression. But they did note the transformation of hormones that hint the three men would have knowledge a decrease in sperm production carried out in accordance with effective contraception.

No severe side-effects were reported either, although a few of the participants reported mild tirednes, acne, or headaches. Five people likewise reported mildly decreased sex drive and two men described mild erectile dysfunction, however, this did not appear to affect sex activity, according to the study. If this sounds a little perturbing, it’s worth remembering the immense inventory of side effects that come with the already commercially available girl contraceptive pill, from humor wavers, headaches, and nausea to lessened libido, weight gain, and increased risk of depression.

“The goal is to find the complex that has the fewest side effects and is the most effective, ” contributed Professor Stephanie Page of the University of Washington School of Medicine. “We are developing two oral narcotics in latitude in an attempt to move the[ contraceptive medicine] arena forward.”

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